Omega‐3 fatty acid supplements and recurrent miscarriage: A perspective on potential mechanisms and clinical evidence

Recurrent miscarriage (RM) affects approximately 1%–5% of couples worldwide. Due to its complicated etiologies, the treatments for RM also vary greatly, including surgery anatomic factors such as septate uterus and uterine adhesions, thyroid modulation drugs hyperthyroidism hypothyroidism, aspirin low molecular weight heparin antiphospholipid syndrome. However, these treatment modalities are still insufficient solve RM. Omega-3 fatty acids reported modulate dysregulation immune cells, oxidative stress, endocrine disorders, inflammation, etc., which closely associated with pathogenesis there is a lack systematic description involvement omega-3 in treating RM, underlying mechanisms not clear. In this review, we sought determine potential that highly regulation on mechanisms. addition, highlighted direct indirect clinical evidence acid supplements treat might encourage application thus improving pregnancy outcomes.